Stress as Both Risk and Mechanism in Alzheimer’s Disease: The Unruly Biomarker
How do chronic stress and breakdowns in stress neuroendocrine systems muddy the waters of Alzheimer’s disease causation, progression, and biomarker interpretation?
Insights
Evidence-Based Clinical AI
AI, biomarkers, and older-adult care. My notes on medical AI, dementia biomarkers, frailty, and older-adult care. This section is supported by my custom AI-assisted literature surveillance workflow that helps me identify recent papers that I then review. Each item is manually curated, edited, and approved before publication. The aim is not to summarize everything. The aim is to notice what may matter clinically, what is fragile, and what still needs to prove itself in real older-adult care.
Latest insights
Real-World AI Use by Hospitalists: Implementation Challenges Outpace Adoption
Does the rapid adoption of LLM-based AI tools by hospitalists translate into improved care, or does implementation quality still limit their clinical impact?
Adjudicating Cardiovascular Events with Adaptive AI: Less Hype, Real Workflow Gains?
Can adaptive AI replicate human adjudication of cardiovascular events with adequate rigor to reduce trial workload without sacrificing accuracy?
Bone Marrow Biopsy Without the Needle? AI Risk Prediction for Myelofibrosis
Can a machine learning model built on routine blood counts and age reliably rule in or out clinically significant bone marrow fibrosis, reducing the need for invasive biopsy?
STAT3 in Alzheimer’s: Master Switch or Mixed Messenger?
Is STAT3 a credible and actionable therapeutic target in Alzheimer’s disease, or just a marker of chronic neuroinflammation?
Patient Education Materials from LLMs: Readable but Not Always Usable
How do LLM-generated patient education materials for surgery care stack up on readability and real-world usability, especially for low-literacy patients?
Bridging Image Interpretation and Segmentation: The Promise and Hurdles of UniBiomed
Does a unified multi-modal model finally make AI image interpretation more grounded and interpretable for clinicians?
AI Outperforming Stroke Experts: Promise and Caution in Acute Lacunar Stroke Diagnosis
How does deep learning stack up against neurologist consensus for diagnosing acute lacunar stroke on CT perfusion—a notoriously difficult task, especially relevant for older adults?
Amyloid PET After Drug Approval: Is More Scanning Better Alzheimer’s Care or a Systemic Bottleneck?
How should health systems integrate amyloid PET into Alzheimer’s care after the rise of anti-amyloid therapies, and does the growing reliance on scanning clarify, or complicate, diagnosis and follow-up?
Wake EEG Slow Waves: A Glimpse Into Preclinical Alzheimer’s Disease?
Can slow waves detected on resting EEG—outside of sleep—serve as accessible, early markers of amyloid pathology and neurodegeneration risk in Alzheimer’s disease?